Danavir 600mg

Danavir 600mg Tablet (Darunavir 600mg)

Description

Danavir 600mg contains Darunavir, an antiretroviral drug used in the treatment of HIV-1 infection and AIDS.

• Due to the risk of resistance, Darunavir is always administered in combination with other antiretroviral drugs such as Ritonavir or Cobicistat.

• Darunavir is a protease inhibitor, blocking the HIV protease enzyme, preventing the formation of mature, infectious viral particles.

Medical Uses / Indications

• HIV-1 infection in adults (in combination with Ritonavir, Cobicistat, or other antiretroviral drugs).

• Pediatric HIV-1 infection (Darunavir + Ritonavir combination).

• Therapy decisions are guided by plasma HIV-1 RNA levels and CD4+ counts.

Mechanism of Action

• Darunavir inhibits HIV-1 protease, an enzyme essential for viral replication.

• Prevents dimerization and catalytic activity of the protease.

• Blocks cleavage of viral Gag-Pol polyproteins, preventing the production of mature infectious virus.

• Its molecular flexibility allows it to remain effective against protease mutations.

Side Effects

Common:

• Nausea, mild stomach pain

• Insomnia

• Itching, rashes

• Fat redistribution (body shape changes)

Serious / Rare:

• Allergic reactions (hives, swelling of face/lips/throat/tongue, difficulty breathing)

• Severe hepatomegaly with steatosis

• Chest discomfort, wheezing

• Increased heart rate, lumbar pain

• Cold sores

Precautions

• Sulfonamide allergy: Use cautiously; Darunavir contains a sulfonamide moiety.

• Drug interactions: May cause life-threatening reactions; avoid contraindicated combinations.

• Hemophilia: Can increase bleeding risk (skin hematomas, hemarthrosis).

• Diabetes mellitus: Monitor blood glucose; may increase glucose levels.

• Fat redistribution: Risk of obesity; common in antiretroviral therapy.

• Immune reconstitution syndrome: May occur; discontinue therapy if severe.

Contraindications / Drug Interactions

• CYP3A interactions: Combination with Ritonavir increases plasma levels; monitor closely.

• Other contraindicated drugs:

  • Alfuzosin → hypotension

  • Dihydroergotamine → peripheral vasospasm/ischemia

  • Cisapride & Pimozide → cardiac arrhythmias

  • Midazolam & Triazolam → respiratory depression

Pregnancy & Lactation

• Pregnancy Category C: Animal studies show potential fetal risk; use only if benefits outweigh risks.

• Breastfeeding: Likely unsafe; consult a doctor before use.

Dosage

• Standard adult dose: 600mg orally twice daily (2 × 300mg) with food.

• Once daily dosing for resistant HIV: 800mg Darunavir + Ritonavir once daily with food.

• With at least one resistance-associated substitution: 600mg Darunavir + 100mg Ritonavir twice daily with food.

Administration: Oral, with food.

Storage

• Store at room temperature (25°C).

• Keep in an airtight container, away from children and pets.

Missed Dose

• Take the missed dose as soon as possible before the next scheduled dose.

• If near the next dose, skip the missed dose and continue regular schedule.

• Consult your doctor for guidance.